tall tropical American timber tree especially abundant in eastern Brazil; yields hard strong durable zebrawood with straight grain and dark strips on a pinkish to . Gonçalo Alves ou Gonçaleiro (Astronium fraxinifolium) Família Anacardiaceae. Árvore rústica de médio porte, comum em várias regiões, ás vezes chamada de. PDF | Essential oils produced from leaves of Astronium fraxinifolium Schott. harvested at four different stages of maturity have been analyzed by GC/MS.
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View at Google Scholar P. Treatment was done by administering OEPA intralesionally i. View at Google Scholar E. In the present study we decided to evaluate two medicinal plants, Plectranthus amboinicus and Astronium fraxinifolium.
Goncalo alves Astronium fraxinifolium
Brazil has reported 23, CLcases in [ 4 ]. The animals were also weighed during this period. The aim of the present work was to evaluate antileishmanial activity of Astronium fraxinifolium and Plectranthus amboinicus. Subscribe to Table of Contents Alerts. Its activities are poorly known unlike the other plant from the same family, M.
Additionally, we decided to use the gold hamster model to evaluate the activity of our plant materials in vivo based on the fact that hamsters are known to be highly susceptible to Leishmania subgenus Viannia infection [ 35 ].
The parasites were fixed in formaldehyde, stained with Trypan blue and visualized at light microscope at x magnification. Not for the casual reader. Looking into the canopy Photograph by: Lesion thickness a and number of parasites b in hamster footpad infected with 10 6 promastigotes of Leishmania braziliensis.
Nonetheless, we decided to test the EOPA treatment in animal models based on data from other researchers [ 33 ] who showed a good antileishmanial activity of essential oil, in the case of Lippia sidoides Cham. Astronium fraxinifolium Schott Anacardiaceae Some works treat this species as a form or just a synonym of Astronium graveolens. Abstract The aim of the present work was to evaluate antileishmanial activity of Astronium fraxinifolium and Plectranthus amboinicus.
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Astronium fraxinifolium – Dictionary Definition :
The ethanolic extracts of the bark, sapwood, and leaves of A. Leishmania amazonensisand L. Lesion thickness of hamster footpad infected with 10 6 promastigotes of Leishmania braziliensis. Pentavalent antimonials are still the treatment of choice for over 50 years; however, they comprise several problems, such as endovenous use and prolonged and high-cost treatment [ 10 ].
As it was shown in our previous study [ 26 ], the major component in essential oil obtained from P. Hamsters treated with 15 daily doses of the plant material showed a profile of lesion thickness similar to those treated with Glucantime, much lower than that observed in the untreated animals Figure 5. The data relating to the parasite load were analyzed using the nonparametric Mann-Whitney test.
The treatment was initiated when the lesions appeared about the 20th day after infection. The aim of the present work was to demonstrate in vitro and in vivo antileishmanial activity of Astronium fraxinifolium and Plectranthus amboinicus.
The first protocol of treatment consisted of ethanolic leaf extract from A.
Hamsters treated with 4 daily doses of ethanolic leaf extract from A. To receive news and publication updates for BioMed Research International, enter your email address in the box below.
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Parasite Load The number of parasites in the lesions was quantified by the limiting dilution technique as previously described [ 30 ]. The lesion sizes from treated and untreated animals were analysed by the one-way Anova and complemented by the Tukey-Kramer test for multiple comparisons. Year ISBN Description An extremely concise book, listing approximately 1, species and varieties of plants with their botanical name, common name in Brazil, regions in Brazil where the plant is found, a brief list of uses and any medically active compounds in the plant.
Another point to take into account is that the drugs available for CL treatment produce significant side effects traxinifolium to their high toxicity and tissue drug accumulation, which includes myalgias, nausea, vomiting, cardiac arrhythmia, hepatitis, or pancreatitis [ 1213 ].
Miltefosine and fluconazole have recently showed effectiveness showed effectiveness against CL [ 1415 ], but despite their lower toxicity, these second line drugs are not useful against other forms of leishmaniasis [ 13 ]. Plectranthus amboinicuspopularly known as malvarisco, a native aromatic plant of India and cultivated in many parts of the world, including Brazil, belongs to the Lamiaceae family and the genus Plectranthus.
No cytotoxic activity of the plant materials was observed when they were incubated in different concentrations with RAW Furthermore, the continuous use of ineffective drugs has led to the development of resistance to their compounds [ 16 ], which have stirred an urgent need for novel, effective, and safe drugs for treatment of leishmaniasis. Axtronium Plants Database, Ken Fern. Carvacrol is a monoterpene phenol, isomer to thymol, and presents various biological activities such as antimicrobial, antitumor, and anti-inflammatory activities [ fraxinifoliuj ].
If you have any useful information about this plant, please leave a comment. Ethanolic extracts from A. Nonetheless, in some cases when mucosa, such as nasal or oral mucosa, is injured, treatment is necessary; otherwise, permanent sequelae may occur [ 7 ]. Sample of the wood Photograph by: